Which cell produces pepsin in the stomach?

• A. Parietal cell
• B. Chief cell
• C. Gastric mucous neck cell
• D. Vascular endothelial cell

Answer: (B)

The production of pepsin in the stomach is primarily the responsibility of chief cells, which are specialized cells located in the gastric glands of the stomach lining. Chief cells secrete pepsinogen, which is an inactive precursor of pepsin. When pepsinogen comes into contact with the acidic environment of the stomach (due to hydrochloric acid secreted by parietal cells), it is activated into pepsin, an enzyme that plays a key role in the digestion of proteins.

This enzymatic process is crucial for the breakdown of dietary proteins into smaller peptides, facilitating further digestion and nutrient absorption in the intestines. The function of chief cells is fundamental to the digestive process, as they are integral in providing the body with active enzymes necessary for effective digestion.

Understanding the role of chief cells in pepsin production helps clarify the broader context of gastric physiology and the digestive processes that occur in the stomach.