What genetic instability characterizes Lynch syndrome?

• A. Instability of mitochondrial DNA
• B. Instability of micro-satellite regions of the genome
• C. Instability of chromosomal regions associated with aging
• D. Instability of nuclear RNA regions

Answer: (B)

Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC), is characterized by microsatellite instability (MSI), which specifically refers to the instability of microsatellite regions in the genome. Microsatellites are short, repetitive sequences of DNA that are prone to replication errors.

In Lynch syndrome, mutations in DNA mismatch repair (MMR) genes, such as MLH1, MSH2, MSH6, and PMS2, lead to a failure to properly repair these errors during DNA replication. This results in an accumulation of mutations in the microsatellite regions, which is a hallmark of this syndrome. Consequently, individuals with Lynch syndrome have an increased risk of various cancers, particularly colorectal and endometrial cancers, due to this genetic instability.

The presence of microsatellite instability can be detected through specific laboratory tests, and serves not only as a diagnostic criterion for Lynch syndrome, but also has implications for screening and managing patients at risk for cancer. This unique aspect of genetic instability highlights the underlying molecular mechanisms that drive tumorigenesis in Lynch syndrome.