In patients with hemochromatosis, which finding is typically noted on liver biopsy?

• A. Excess copper deposits
• B. Excess iron deposition in hepatocytes
• C. Fibrosis of portal triads
• D. Infiltration of plasma cells

Answer: (B)

In hemochromatosis, the primary pathological finding on liver biopsy is the excessive deposition of iron in hepatocytes. This condition is characterized by increased intestinal absorption of iron, leading to accumulation in various organs, particularly the liver. On histological examination, the liver tissue will show a marked increase of excess iron deposits, which can be visualized using special staining techniques such as Prussian blue stain. This stain highlights the iron deposits, making them detectable under the microscope.

The presence of excess iron in hepatocytes is crucial for diagnosing hemochromatosis and helps in understanding the associated risks for liver damage, cirrhosis, and even hepatocellular carcinoma. Therefore, recognizing these iron deposits is essential in managing patients with this condition.