A deficiency in which vitamin leads to inadequate hydroxylation of procollagen?

• A. Vitamin A
• B. Vitamin C
• C. Vitamin D
• D. Vitamin K

Answer: (B)

A deficiency in vitamin C leads to inadequate hydroxylation of procollagen because vitamin C is a crucial cofactor for the enzymes involved in this process. Specifically, vitamin C is necessary for the activity of prolyl and lysyl hydroxylase, enzymes that hydroxylate proline and lysine residues in procollagen. This hydroxylation is vital for the stability and proper formation of collagen molecules. Without sufficient hydroxylation, collagen cannot form effectively, leading to conditions such as scurvy, which is characterized by symptoms like weakened connective tissues, easy bruising, and poor wound healing.

In contrast, other vitamins mentioned do not play a direct role in collagen synthesis and modification; for example, vitamin A is involved in vision and immune function, vitamin D is essential for calcium homeostasis and bone health, and vitamin K is primarily associated with blood clotting processes.